Sustainable C-X and C-H functionalization catalyzed by CuIII species
Researcher in charge: Xavi Ribas
Copper-catalyzed cross-coupling reactions for the formation of aryl−heteroatom bonds (Ullmann reaction) is currently a hot topic, due to the importance of developing new sustainable synthetic tools. For the past 10 years many copper-mediated or catalyzed procedures have been developed, usually by activation of aryl halide substrates. However, several mechanistic key aspects are still under debate. Our goal is to design new catalysts capable of effecting the desired transformations under mild conditions. A breakthrough finding of our group has been the recognition of the CuI/CuIII catalytic redox cycle as a viable mechanism in Ullmann-type catalysis.
The development of more sustainable direct C-H functionalization reactions, catalyzed by transition-metals, is another enormous challenge, Our research is focused on the quest of cheaper and less toxic first-row transition metal activation of C-H bonds, with the understanding of the molecular mechanism of such transformations as a major goal.